Study of molecular rotational isomerism using deuterium NMR in chiral oriented solvents.
نویسندگان
چکیده
Deuterium NMR in polypeptide chiral liquid crystals is used for the first time to investigate the internal rotational isomerism phenomenon, illustrated by the interconversion between conformers of 1-(2,6-dideutero-4-methylphenyl)naphthalene
منابع مشابه
Natural abundance deuterium NMR spectroscopy in polypeptide liquid crystals as a new and incisive means for the enantiodifferentiation of chiral hydrocarbons.
Polymeric chiral liquid-crystalline solvents based on homopolypeptides are of interest with the view to discriminate between enantiomeric pairs of chiral hydrocarbons using proton-decoupled deuterium one- and two-dimensional NMR spectroscopy at natural abundance level. This method offers the major advantage that neither chemical modification nor isotopic labelling of the solutes to be studied i...
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Methods for the assignment of the quadrupolar doublets in the deuterium NMR spectra of weakly ordered, perdeuterated or partially deuterated enantiomers dissolved in chiral liquid crystals are described which use robust 2D correlation NMR experiments. To overcome a lack of resolution in deuterium tilted Q-COSY 2D spectra in such materials, we propose and explore a correlation 2D sequence which ...
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We describe several two-dimensional NMR experiments to facilitate the analysis of overcrowded proton-decoupled deuterium spectra of chiral molecules oriented in poly-γ-benzyl-L-glutamate liquid crystalline solutions. These 2D NMR experiments allow the correlation between the components of each quadrupolar doublet in the deuterium spectra and then their assignment on the basis of chemical shift....
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Previous experimental natural abundance deuterium (NAD) NMR results have shown an odd/even-related alternation in the ((2)H/(1)H) ratio of the methylene groups of fatty acids (ChemBioChem 2001, 2, 425) and, by NAD NMR in CLC, a marked difference between enantiotopic deuterons for each methylenic site (Anal. Chem. 2004, 76, 2827). However, to date, the assignment of the absolute configuration fo...
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The enantioselective potentialities of three polypeptide liquid-crystalline solutions made of poly-gamma-benzyl-L-glutamate (PBLG), poly-gamma-ethyl-L-glutamate (PELG) or poly-epsilon-carbobenzyloxy-L-lysine (PCBLL) are investigated and compared using proton, carbon-13 and deuterium NMR spectroscopy. From a practical point of view, we propose an efficient alternative to the PBLG system, which i...
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ورودعنوان ژورنال:
- Chemical communications
دوره 4 شماره
صفحات -
تاریخ انتشار 2006